Which organ is most affected by cystic fibrosis?

Cystic fibrosis is a genetic disorder that primarily affects the respiratory system, making the lungs the most significantly impacted organ. In individuals with cystic fibrosis, mutations in the CFTR gene lead to the production of thick, sticky mucus that obstructs the airways and traps bacteria, resulting in chronic lung infections, inflammation, and eventual lung damage. The accumulation of mucus in the lungs hinders airflow and promotes a cycle of infection and inflammation that can lead to respiratory failure if not managed properly.

While cystic fibrosis can affect other organs, such as the pancreas and intestines, it is the lungs where the most severe complications typically arise. Patients often experience difficulty breathing and require extensive respiratory care. Therefore, the lungs are categorized as the organ most affected by cystic fibrosis, which explains the choice provided in the question.